Alan Chait MD - Expanded Publication List

Boren J, Olin K, Lee I, Chait A, Wight TN, Innerarity TL:  Identification of the principal proteoglycan-binding site in LDL:  A single point mutation in apo B100 severely affects proteoglycan interaction without affecting LDL receptor binding.  J Clin Invest 101:2658-2664, 1998.

Chang MY, Olin K, Tsoi C, Wight TN, Chait A:  Human monocyte-derived macrophages secrete two forms of proteoglycan-macrophage colony stimulating factor  that differ in their ability to bind low density lipoproteins.  J Biol Chem 273:15985-15992, 1998.

Crawford RS, Kirk EA, Rosenfeld ME, LeBoeuf RC, Chait A:  Dietary antioxidants inhibit the development of fatty streak lesions in the LDL receptor-deficient mouse.  Arterioscler Thromb Vasc Biol 18:1506-1513, 1998.

O’Brien KD, Olin KL, Alpers CE, Chiu W, Ferguson M, Hudkins K, Wight TN, Chait A:  A comparison of apolipoprotein and proteoglycan deposits in human coronary athero-sclerotic plaques:  Co-localization of biglycan with apolipoproteins. Circulation 98:519-527, 1998.

Crawford RS, Mudaliar SR, Henry RR, Chait A:  Inhibition of low density lipoprotein oxidation in vitro but not ex vivo by troglitazone.  Diabetes 48:783-790, 1999.

Olin KL, Potter-Perigo S, Barrett H, Wight TN, Chait A:  Lipoprotein lipase enhances the binding of native and oxidized low density lipoproteins to versican and biglycan synthesized by cultured arterial smooth muscle cells.  J Biol Chem 274:34629-34636, 1999.

Kawamura M, Heinecke JW, Chait A:  Increased uptake of alpha-hydroxy aldehyde modified low density lipoprotein by macrophage scavenger receptors.  J Lipid Res 41:1054-1059, 2000.

Chang MY, Potter-Perigo S, Tsoi C, Chait A, Wight TN:  Oxidized low density lipoproteins regulate synthesis of monkey aortic smooth muscle cell proteoglycans that have enhanced native low density lipoprotein binding properties.  J Biol Chem 275:4766-4773, 2000.

Chait A, Wight TN:  Interaction of native and modified low-density lipoproteins with extracellular matrix.  Curr Opin Lipidol 11:457-463, 2000.

Olin KL, Potter-Perigo S, Barrett PH, Wight TN, Chait A:  Biglycan, a vascular proteoglycan, binds differently to HDL(2) and HDL(3): role of apoE.  Arterioscler Thromb Vasc Biol 21:129-135, 2001.

Chang MY, Potter-Perigo S, Wight TN, Chait A:  Oxidized LDL bind to nonproteoglycan components of smooth muscle extracellular matrices.  J Lipid Res 42:824-833, 2001.

Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ:  Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease.  N Engl J Med 345:1583-1592, 2001.

Tannock LR, Little PJ, Wight TN, Chait A:  Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL.  J Lipid Res 43:149-157, 2002.

Tannock LR, Olin KL, Barrett PH, Wight TN, Chait A:  Triglyceride-rich lipoproteins from subjects with type 2 diabetes do not demonstrate increased binding to biglycan, a vascular proteoglycan.  J Clin Endocrinol Metab 87:35-40, 2002.

Little PJ, Tannock LR, Olin KL, Chait A., Wight TN:  Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-beta1 exhibit increased binding to LDLs.  Arterioscler Thromb Vasc Biol 22:55-60, 2002.

Olin-Lewis, KL Benton, JL, Rutledge JC, Baskin DG, Wight TN, Chait A:  Apolipoprotein E mediates the retention of high density lipoproteins by mouse carotid arteries and cultured arterial smooth muscle cell extracellular matrices.  Circ Res 90:1333-1339, 2002.

Olin-Lewis KL., Krauss RM, La Belle M, Blanche PJ, Barrett PHR, Wight TN, Chait A:  Apo C-III content of apo B-containing lipoproteins is associated with binding to the vascular proteoglycan, biglycan.  J Lipid Res 43:1969-77, 2002.

Meyers CD, Tannock LR, Wight TN, Chait A:  Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL.  J Lipid Res 44:2152-2160, 2003.

Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O’Brien KD, Chait A, Kahn SE:  The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.  Diabetologia 46:71-79, 2003.

Chang MY, Tsoi C, Wight TN, Chait A:  Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. Arterioscler Thromb Vasc Biol 23:809-815, 2003.

Herbst KL, Tannock LR, Deeb SS, Purnell JQ, Brunzell JD, Chait A:  Kobberling type of familial partial lipodystrophy: an underrecognized syndrome.  Diab Care 26:1819-1824, 2003.

O’Brien KD, Vuletic S, McDonald TO, Wolfbauer G, Lewis K, Tu AY, Marcovina S, Wight TN, Chait A, Albers JJ:  Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis.  Circulation 108:270-274, 2003.

Lewis KE, Kirk EA, McDonald TO, Wang S, Wight TN, O’Brien KD, Chait A:  Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice.  Circulation 110:540-545, 2004.

Renard CB, Kramer F, Johansson F, Lamharzi N, Tannock LR, von Herrath MG, Chait A, Bornfeldt KE:  Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions.  J Clin Invest 114:659-668, 2004.

Lamharzi N, Renard CB, Kramer F, Pennathur S, Heinecke JW, Chait A, Bornfeldt KE:  Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL.  Diabetes 53:3217-3225, 2004.

Bergt C, Pennathur S, Fu X, Byun J, O’Brien K, McDonald TO, Singh P, Chait A, Brunzell J, Geary RL, Oram JF, Heinecke JW:  The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.  Proc Natl Acad Sci USA 101:13032-13037, 2004.

O’Brien KD, Lewis K, Fischer JW, Johnson P, Hwang JY, Knopp EA, Kinsella M, Barrett PHR, Chait A, Wight TN:  Smooth muscle cell biglycan overexpression results in increased lipoprotein retention on extracellular matrix:  implications for the retention of lipoproteins in atherosclerosis.  Atherosclerosis 177:29-35, 2004.

Chait A, Han CY, Oram JF, Heinecke JW:  Thematic review series:  The immune system and atherogenesis.  Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?  J Lipid Res 46:389-403, 2005.

Tannock LR, O’Brien KD, Knopp RH, Retzlaff B, Fish B, Wener MH, Kahn SE, Chait A:  Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects.  Circulation 111:3058-3062, 2005.

O’Brien KD, McDonald TO, Kunjathoor V, Eng K, Knopp EA, Lewis K, Lopez R, Kirk EA, Chait A, Wight TN, deBeer FC, LeBoeuf RC:  Serum amyloid A and lipoprotein retention in murine models of atherosclerosis.  Arterioscler Thromb Vasc Biol 25:785-790, 2005.

Chang MY, Han CY, Wight TN, Chait A:  Antioxidants inhibit the ability of lysophosphatidylcholine to regulate proteoglycan synthesis.  Arterioscler Thromb Vasc Biol 26:494-500, 2006.

Takeshita J, Byun J, Nhan TQ, Pritchard DK, Pennathur S, Schwartz SM, Chait A, Heinecke JW:  Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue:  A potential pathway for somatic mutagenesis by macrophages.  J Biol Chem 281:3096-3104, 2006.

O’Brien KD, Chait A: Serum Amyloid A:  the “other” inflammatory protein.  Curr Atheroscler Rep 8:62-68, 2006.

Han CY, Chiba T, Campbell JS, Fausto N, Chaisson M, Orasanu G, Plutzky J, Chait A:  Reciprocal and co-ordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes.  Arterioscler Thromb Vasc Biol 26:1806-1813, 2006.

Tannock LR, Kirk EA, King VL, LeBoeuf R, Wight TN, Chait A:  Glucosamine supplementation accelerates early but not late atherosclerosis in LDL receptor-deficient mice.  J Nutr 36:2856-2861, 2006.

Coenen KR, Gruen ML, Chait A, Hasty AH:  Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue.  Diabetes 56:564-573, 2007.

Chira EC, McMillen TS, Wang S, Haw A 3rd, O’Brien KD, Wight TN, Chait A:  Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice.  Atherosclerosis 195:100-109, 2007.

McDonald TO, Gerrity RG, Jen C, Chen HJ, Wark K, Wight TN, Chait A, O'Brien KD:  Diabetes and arterial extracellular matrix changes in a porcine model of atherosclerosis.  J Histochem Cytochem 55:1149-1157, 2007.

Han CY, Subramanian S, Chan CK, Omer M, Chiba T, Wight TN, Chait A:  Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion.  Diabetes 56:2260-2273, 2007.

Vaisar T, Pennathur S, Green PS, Gharib SA, Hoofnagle AN, Cheung MC, Byun J, Vuletic S, Kassim S, Singh P, Chea H, Knopp RH, Brunzell J, Geary R, Chait A, Zhao XQ, Elkon K, Marcovina S, Ridker P, Oram JF, Heinecke JW:   Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.  J Clin Invest 117:746-756, 2007.

Saraswathi V, Gao L, Morrow JD, Chait A, Niswender KD, Hasty AH:  Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice.  J Nutr 137:1776-1782, 2007.

Coenen KR, Gruen ML, Chait A, Hasty AH:  Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue.  Diabetes 56:564-573, 2007.

Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke J, Bornfeldt K:  Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.  Proc Natl Acad Sci 105:2082-2087, 2008.

Subramanian S, Han CY, Chiba T, McMillen TS, Wang SA, Haw A, Kirk EA, O’Brien KD, Chait A:  Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice.  Arterioscler Thromb Vasc Biol 28:685-691, 2008.

Chiba T, Shinozaki S, Nakazawa T, Kawakami A, Ai M, Kaneko E, Kitagawa M, Kondo K, Chait A, Shimokado K:  Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice.  Atherosclerosis 196:68-75, 2008.

Mazzone T, Chait A, Plutzky J:  Cardiovascular disease risk in type 2 diabetes mellitus:  Insights from mechanistic studies.  Lancet 371:1800-1809, 2008.

Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW:  Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of pheripheral insulin resistance.  Arterioscler Thromb Vasc Biol 28:1982-8, 2008.

Chiba, T., Shinozaki, S., Nakazawa T., Kawakami, A., Ai, M., Kaneko, E., Kitagawa, M., Kondo, K., Chait, A., Shimokado, K.:  Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice.  Atherosclerosis 196:68-75, 2008.

Subramanian, S., Chait, A.:  The effect of dietary cholesterol on macrophage accumulation in adipose tissue:  Implications for systemic inflammation and atherosclerosis.  Curr Opin Lipidol 20:39-44, 2009.

Chait, A., Bornfeldt, K.E.:  Diabetes and atherosclerosis:  Is there a role for hyperglycemia?  J Lipid Res 50:S335-S339, 2009.

Chiba, T., Han, C.Y., Vaisar, T., Shimokado, K., Kargi, A., Chen M.H., Wang, S., McDonald, T.O., O’Brien K.D., Heinecke, J.W., Chait, A.: Serum amyloid A3 does not contribute to circulating SAA levels.  J Lipid Res 50:1353-1362, 2009.

Zhao, X.Q., Krasuski, R.A., Baer, J., Whitney, E.J., Neradilek, B., Chait, A., Marcovina, S., Albers, J.J., and Brown, B.G.,: Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: A combined analysis of the familial atherosclerosis treatment study (FATS), the HDL-Atherosclerosis treatment study (HATS), and the armed forces regression study (AFREGS).  Am J Cardiol 104:1457-1464, 2009.

Han, C.Y., Kargi, A.Y., Omer, M., Chan, C.K., Wabitsch, M., O’Brien, K.D., Wight, T.N., Chait, A.: Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation.  Diabetes 59:386-396, 2010.

Hoofnagle, A.N., Vaisar, T., Mitra, P., and Chait, A.:  HDL lipids and insulin resistance.  Curr Diabetes Rep 10:78-86, 2010.

Schauer, I.E., Knaub, L.A., Lloyd, M., Watson, P.A., Gliwa, C., Lewis, K.E., Chait, A., Klemm, D.J., Gunter, J.M., Bouchard, R., McDonald, T.O., O'Brien, K.D., and Reusch, J.E.: CREB downregulation in vascular disease: a common response to cardiovascular risk. Arterioscler Thromb Vasc Biol 30:733-741, 2010.

Campbell, L.A., Yaraei, K., Van Lenten, B., Chait, A., Blessing, E., Kuo, C.C., Nosaka, T., Ricks, J., Rosenfeld, M.E.: The acute phase reactant response to respiratory infection with Chlamydia pneumoniae: implications for the pathogenesis of atherosclerosis. Microb Infect 2010, in press.