Brent Wisse MD - Expanded Publication List

You-Ten EK, Seemayer TA, Wisse BE, Lapp WS. Induction of a glucocorticoid sensitive F1 anti-parental mechanism that affects engraftment during graft-versus-host disease. J. Immunol. 155: 172-180, 1995.

Wisse BE, Campfield LA, Marliss EB, Morais JA, Tenenbaum R, Gougeon R. Effect of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentrations in obese women. Am J Clin Nutr. 70:321-330, 1999.

Wisse BE, Frayo RS, Schwartz MW, Cummings DE. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology. 142:3292-3301, 2001.

Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 50:1714-1719, 2001.

Wisse BE, Schwartz MW. Role of melanocortins in control of obesity. Lancet. 358:857-859, 2001.

Wisse BE, Schwartz MW. The skinny on neurotrophins. Nat Neurosci. 6:655-656, 2003.

Wisse BE, Schwartz MW, Cummings DE. Melanocortin signaling and anorexia in chronic disease states. Ann N Y Acad Sci. 994:275-281, 2003.

Wisse BE, Ogimoto K, Morton GJ, Wilkinson CW, Frayo RS, Cummings DE, Schwartz MW. Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab. 287:E1107-1113, 2004.

Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol. 15:2792-2800, 2004.

Wisse BE, Ogimoto K, Schwartz MW. Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins. Peptides. 27:265-273, 2006.

Ogimoto K, Harris MK Jr, Wisse BE. MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology. 147:4445-4453, 2006.

Wisse BE, Ogimoto K, Morton GJ, Williams DL, Schwartz MW. Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance. Brain Res. 1144:1101-6, 2007.

Wisse BE, Ogimoto K, Tang J, Harris MK Jr, Raines EW, Schwartz MW. Evidence that LPS-induced anorexia depends upon central, rather than peripheral, inflammatory signals. Endocrinology. 148:5230-5237, 2007.

Klaff LS, Wisse BE. Current controversy related to glucocorticoid and insulin therapy in the intensive care unit. Endocr Pract. 13:542-549, 2007.

Wisse BE, Kim F, Schwartz MW. Physiology. An integrative view of obesity. Science. 318:928-929, 2007.

Kim F, Pham M, Maloney E, Rizzo N, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW. Vascular Inflammation, Insulin Resistance and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance. Atheroscler Thromb Vasc Biol. 28:1982-1988, 2008. PMCID: PMC2577575.

Blevins JE, Morton GJ, Williams DJ, Caldwell DW, Bastian LS, Wisse BE, Schwartz MW, and Baskin DG. Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8. Am J Physiol Regul Integr Comp Physiol. 296:R476-484, 2009.

Wisse BE, Schwartz MW. Does hypothalamic inflammation cause obesity? Cell Metabolism. 10:241-242, 2009.

Thompson R, Schreuder AB, Wisse B, Jarman K, Givan K, Suhr L, Corl D, Pierce B, Knopp R, Goss JR. Improving insulin ordering safely: the development of an inpatient glycemic control program. J Hosp Med. 4:E30-35, 2009.

Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW. Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses. Endocrinology. 150:5362-5372, 2009. PMCID: PMC2795721.

Chiu HK, Qian K, Ogimoto K, Morton GJ, Wisse BE, Agrawal N, MacDonald T, Schwartz, MW, Dichek HL.  Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis. Endocrinology. 151:993-1001, 2010.  PMCID: PMC2840680.

Kaiyala KJ, Morton GJ, Leroux BG, Ogimoto K, Wisse BE and Schwartz MW. Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes. 59:1657-1666, 2010. PMCID: PMC2889765.

Oh-I S, Thaler JP, Ogimoto K, Wisse BE, Morton GJ, and Schwartz MW. Central administration of Interleukin-4 exacerbates hypothalamic inflammation and weight gain during hig-fat feeding. Am J Physiology. 299:E47-53, 2010. PMCID: PMC2904047.

Choi SJ, Kim F, Schwartz MW and Wisse BE. Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am J Physiology. 298:E1122-1130, 2010. PMCID: PMC2886534.

German J, Wisse BE, Thaler JP, Oh-I S, Sarruf DA, Ogimoto K, Kaiyala K, Fischer JD, Matsen ME, Taborsky GJ, Schwartz MW, and Morton GJ. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes. Diabetes. 59:1626-1634, 2010. PMCID: PMC2889761.