Christiane Hampe PhD - Expanded Publication List

Steed J, Gilliam LK, Harris RA, Lernmark A, Hampe CS Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein J Immunol Methods  334:114-21 2008.

Raju R, Hampe CS  Immunobiology of stiff-person syndrome Int Rev Immunol;27:79-92 2008.

Oak S, Gilliam LK, Landin-Olsson M, Törn C, Kockum I, Pennington CR, Rowley MJ, Christie MR, Banga JP, Hampe CS The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes Proc Natl Acad Sci USA 105:5471-6 2008.

Nalini R, Gaur LK, Maldonado M, Hampe CS, Rodriguez L, Garza G, Lernmark A, Balasubramanyam A HLA class II alleles specify phenotypes of Ketosis-Prone Diabetes (KPD) Diabetes Care. 2008.

Maruyama T, Oak S, Shimada A, Hampe CS GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adults (LADA) patients Diabetes Care 2008.

Lewy H, Hampe CS, Kordonouri O, Haberland H, Landin-Olsson M, Torn C, Laron Z  Seasonality of Month of Birth differs between Type 1 Diabetes patients with pronounced beta cell autoimmunity and individuals with lesser or absent beta cell autoimmunity Pediatr Diabetes 9:46-52 2008.

Hall T R, Bogdani M, LeBoeuf R, Kirk, E, Maziarz M, Banga J P, Oak, S, Pennington C, Hampe CS  Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies Immunology;123:547-54 2008.

Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ C-terminal clustering of autoantibody and T cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity Diabetes 57:1293-301 2008.

Balasubramanyam A, Nalini R, Hampe CS, Maldonado M Syndromes of Ketosis-Prone Diabetes Mellitus Endocr Rev  29:292-302 2008.

Hampe CS, Nalini R, Maldonado MR, Hall TR, Garza G, Iyer D, Balasubramanyam A.  Association of amino-terminal-specific anti-glutamate decarboxylase (GAD65) autoantibodies with beta cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis prone diabetes mellitus J Clin Endocrinol Metab  92:462-7, 2007.

Fenalti G, Hampe CS, O'Connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O.  Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11 Mol Immunol  44:1178-89, 2007.

Hampe, CS Hall, TR, Agren, A, Rolandsson O Longitudinal changes in Epitope recognition of Autoantibodies against Glutamate decarboxylase 65 (GAD65Ab) in Prediabetic Adults Developing Diabetes Clin Exp Immunol 148:72-8 2007.

Bekris, LM, Jensen, RA, Lagerquist, E, Hall, TR, Agardh CD, Cilio CM, Lethagen AL, Lernmark, A, Robertson RA, Hampe CS GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination Diabet Med 24:521-6 2007.

Fenalti G,  Law RHP, Buckle AM, Langendorf C, Tuck K, Rosado CJ,  Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI,  Mackay IR,  Rowley MJ,  Whisstock JC   GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop Nat Struct Mol Biol 14:280-6 2007.

Maruyama T, Oak S, Hall TR, Banga JP, Ortqvist E, Ettinger RA, Endl  J, Hampe CS  Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high risk HLA class II alleles Clin Exp Immunol  150:416-21 2007.

Balasubramanyam A, Garza G, Rodriguez L, Hampe CS, Gaur L, Lernmark A, Maldonado MR. Accuracy and predictive value of classification schemes forketosis-prone diabetes Diabetes Care 29:2575-9,  2006.

Hall TR, Thomas JW, Padoa CJ, Torn C, Landin-Olsson M, Ortqvist E, Hampe CS.   Longitudinal epitope analysis of insulin-binding antibodies in type  1 diabetes Clin Exp Immunol 146:9-14, 2006.

Schlosser M, Banga JP, Madec AM, Binder KA, Strebelow M, Rjasanowski I, Wassmuth R, Gilliam LK, Luo D, Hampe CS Dynamic Changes of GAD65Ab Epitope Specificities during Progression to Type 1 Diabetes Diabetologia 48: 922-30 2005.

Padoa CJ, Crowther NJ, Thomas JW, Lernmark A, Ortqvist E, Palmer JP, Luo D, Hampe CS Epitope mapping of Insulin Autoantibodies using recombinant Fab Clin Exp Immunol 140: 564-71 2005.

Raju R, Foote J, Banga JP, Hall TR, Padoa CJ, Dalakas MC, Ortqvist E, Hampe CS   Analysis of GAD65 Autoantibodies in Stiff Person Syndrome Patients J Immunol 175:7755-62 2005.

Maldonado M, Hampe CS, Iyer D, Gaur LK, Hammerle LP, Bolgiano D, Rodriguez L, Rajan A, Lernmark Å, Balasubramanyam   Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes J Clin Endocrinol Metab  88:5090-8, 2003.

Padoa CJ, Banga JP, Madec AM, Ziegler M, Schlosser M, Oertqvist E, Kockum I, Palmer J, Rolandsson O, Foote J, Hampe CS  Recombinant Fab of human mAbs specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Ab Diabetes, 52:2689-95, 2003.

Hampe CS, Hammerle LP, Bekris L, Örtqvist E, Persson B, and Lernmark Å  Stable GAD65 Autoantibody Epitope Patterns in Type 1 Diabetes Children Five Years after Onset J Autoimmun 18: 49-53 2002.

Hampe CS, Lundgren P, Daniels TL, Hammerle LP, Marcovina SM, and Lernmark  Å  A Novel Monoclonal Antibody Specific for the N-Terminal End of GAD65 J Neuroimmunol 113:63-71 2001.

Hampe CS, Hammerle LP, Falorni A, Robertson J and Lernmark Å Site-Directed Mutagenesis of K396R of the 65 kDa Glutamic Acid Decarboxylase active Site Inhibits Enzyme Activity but not Antibody Binding FEBS Lett 488:185-9 2001.