David Cummings MD - Expanded Publication List

Fornace AJ, Cummings DE, Comeau CM, Kant JA, Crabtree GR.  Single-copy inverted repeats associated with regional genetic duplications in gamma fibrinogen and immunoglobulin genes.  Science 224:161-164 (1984).

Beck BN, Frelinger JG, Shigeta M, Infante AJ, Cummings DE, Hammerling G, Fathman CG.  T cell clones specific for hybrid I-A molecules. Discrimination with monoclonal anti-I-Ak antibodies.  J Exp Med 156:1186-94 (1982).

Ceredig R, Cummings DE.  Phenotypic and functional properties of murine thymocytes. III. Kinetic analysis of the recovery of intrathymic cytolytic T lymphocyte precursors after in vivo administration of hydrocortisone acetate.  J Immunol 130:33-37 (1983).

Fornace AJ, Cummings DE, Comeau CM, Kant JA, Crabtree GR.  Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces gamma A and gamma B forms of gamma-fibrinogen.  J Biol Chem 259:12826-12830 (1984).

Galvin K, Krishna S, Ponchel F, Frohlich M, Cummings DE, Carlson R, Wands JR, Isselbacher KJ, Pillai S, Ozturk M.  The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene.  Proc Natl Acad Sci USA 89:8452-8456 (1992).

Cummings DE, Edelhoff S, Disteche CM, McKnight GS.  Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.  Mamm Genome 5:701-706 (1994).

Cummings DE, Bremner WJ.  Prospects for new hormonal male contraceptives.  Endocrinol Metab Clin North Am 23:893-922 (1994).

Cummings DE, Brandon EP, Planas J, Idzerda R, McKnight GS.  Genetically lean mice derived by targeted disruption of the RII subunit of protein kinase A.  Nature 382:622-626 (1996).

Amieux PS, Cummings DE, Motamed K, Brandon EP, Wailes L, Le K, Idzerda RL, McKnight GS.  Compensatory regulation of RI protein levels in protein kinase A mutant mice.  J Biol Chem 272:3993-3998 (1997).

McKnight GS, Cummings DE, Amieux PS, Sikorski MA, Brandon EP, Planas JV, Motamed K, Idzerda RL.  Cyclic AMP, PKA, and the physiological regulation of adiposity.  Rec Prog Horm Res 53:139-161 (1998).

Weigle D.S, Selfridge LE, Schwartz MW,  Seeley RJ, Cummings DE, Havel PJ, Kuijper JL.  Elevated free fatty acids induce uncoupling protein 3 expression in muscle:  A potential explanation for the effect of fasting.  Diabetes 47:298-302 (1998).

Cummings DE, Kumar N, Bardin CW, Sundaram K, Bremner WJ.  Prostate-sparing effects in primates of the potent androgen 7-methyl-19-nortestosterone:  A potential alternative to testosterone for androgen replacement and male contraception.  J Clin Endocrinol Metab 83:4212-4219 (1998).

Cummings DE.  Insights into the genetics of obesity from transgenic and knockout mice.  J Nutr 129:791-795 (1999).

Cummings DE, Planas JV, Idzerda RL, McKnight GS.  Mutation of the RII subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue.  J Biol Chem 274:36281-36287 (1999).

Wu JY, Ribar TJ, Cummings DE, Burton KA, McKnight GS, Means AR.  Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4.  Nature Genetics 25:448-452 (2000).

Cummings DE, Schwartz MW.  Melanocortins and body weight:  a tale of two receptors.  Nature Genetics 26:8-9 (2000).

Mystkowski P, Shankland E, Schreyer SA, LeBoeuf RC, Schwartz RS, Cummings DE, Kushmerick M, Schwartz MW.  Validation of whole-body magnetic resonance spectroscopy as a tool to assess murine body composition.  Int J Obes Relat Metab Disord 24:719-724 (2000).

Cummings DE, Merriam GR.  Age-related changes in growth hormone secretion:  Should the somatopause be treated?  Semin Reprod Endocrinol 17:311-325 (2000).

Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS.   A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.  Diabetes 50:1714-1719 (2001).

Wisse B, Frayo S, Schwartz, MS, Cummings DE.  Reversal of cancer anorexia by blockade of central melanocortin receptors in rats.  Endocrinology 142:3292-3301 (2001).

Schreyer SA, Cummings DE, McKnight GS, LeBoeuf RC.  Mutation of the PKA RII subunit prevents diet-induced insulin resistance and dyslipidemia.  Diabetes 50:2555-2562 (2001).

Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ.  Human plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.  New Engl J Med 346:1623-1630 (2002).

Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS.  Elevated plasma ghrelin levels in Prader-Willi syndrome. 
Nature Medicine 8:643-644 (2002).

Cummings DE, Purnell JQ, Weigle DS.  Weight loss and plasma ghrelin levels. 
New Engl J Med 347:1379-1381 (2002).

Weigle DS, Cummings DE, Newby PD, Breen PA, Frayo RS, Matthys CC, Callahan HS, Purnell JQ.  Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet.  J Clin Endocrinol Metab 88:1577-1586 (2003).

Williams DL, Cummings DE, Grill HJ, Kaplan JM.  Meal-related ghrelin suppression requires post-gastric feedback.  Endocrinology 144:2765-2767 (2003).

Cummings DE, Merriam GR.  Growth hormone therapy in adults. Annual Review of Medicine  54:513-533 (2003).

Cummings DE, Schwartz MW.  Genetics and pathophysiology of human obesity. Annual Review of Medicine 54:453-471 (2003).

Levin BE, Dunn-Meynell AA, Ricci MR, Cummings DE.  Abnormalities of ghrelin and leptin regulation in obesity-prone juvenile rats.  Am J Physiol Endocrinol Metab 285:E949-957 (2003).

Cummings DE.  The stomach and weight reduction: the role of ghrelin.  Gastroenterology 124:575-577 (2003).

Faulconbridge LF, Cummings DE, Kaplan JM, Grill HJ.  Hyperphagic effects of brainstem ghrelin administration.  Diabetes 52:2260-2265 (2003).

Haqq AM, Stadler DD, Rosenfeld R, Pratt K, Weigle DS, Frayo RS, LaFranchi SH, Cummings DE, Purnell JQ.  Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome.  J Clin Endocrinol Metab 88:3573-3576 (2003).

Williams DL, Grill HJ, Cummings DE, Kaplan JM.  Vagotomy dissociates short- and long-term controls of circulating ghrelin.  Endocrinology 144:5184-5187 (2003).

Cummings DE, Shannon MH.  Roles for ghrelin in the regulation of appetite and body weight.  Archives of Surgery 138:389-396 (2003).

Cummings DE, Foster KE.  Ghrelin-leptin Tango in body-weight regulation.  Gastroenterology 124:1532-1535 (2003).

Purnell JQ, Weigle DS, Breen P, Cummings DE.  Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans.  J Clin Endocrinol Metab 88:5747-5752 (2003).

Wisse BE, Schwartz MW, Cummings DE.  Melanocortin signaling and anorexia in chronic disease states.  Proc NY Acad Sci 994:275-282 (2003).

Cummings DE, Shannon MH.  Ghrelin and gastric bypass: Is there a hormonal contribution to surgical weight loss?  J Clin Endocrinol Metab 88:2999-3002 (2003).

Callahan HS, Cummings DE, Pepe MS, Breen PA, Matthys CC, Weigle DS.  Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict inter-meal interval in humans.  J Clin Endocrinol Metab 89:1319-1324 (2004).

McLaughlin T, Abbasi F, Lamendola C, Frayo RS, Cummings DE.  Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls.  J Clin Endocrinol Metab 89:1630-1635 (2004).

Cummings DE, Overduin J, Foster-Schubert KE.  Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution.  J Clin Endocrinol Metab 89:2608-2615 (2004).

Gelling RW, Overduin J, Morrison CD, Morton GJ, Frayo RS, Cummings DE, Schwartz MW.  Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding.  Endocrinology 145:4575-4582 (2004).

Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D.  Plasma ghrelin levels and hunger scores among humans initiating meals voluntarily in the absence of time- and food-related cues.  Am J Physiol Endocrinol Metab 287:E297-304 (2004).

Cummings DE.  Helicobacter pylori and ghrelin: inter-related players in body-weight regulation?  Amer J Med 117:436-439 (2004).

Wisse BE, Ogimoto K, Morton GJ, Wilkinson CW, Frayo RS, Cummings DE, Schwartz MW.  Physiological regulation of hypothalamic interleukin-1beta (IL-1) gene expression by leptin and glucocorticoids: implications for energy homeostasis.  Am J Physiol Endocrinol Metab 287:E1107-1113 (2004).

Newhall KJ, Cummings DE, Nolan MA, McKnight GS.  Deletion of the RII subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouse.  Molecular Endocrinology 19:982-991 (2005).

Himmerich H, Fulda S, Kunzel HE, Pfennig A, Dzaja A, Cummings DE,  Pollmacher T.  Ghrelin plasma levels during psychopharmacological treatment. Neuropsychobiology 52:11-16 (2005).

Williams DL, Cummings DE.  Regulation of ghrelin in physiologic and pathophysiologic states.  J Nutrition 135:1320-1325 (2005).

Hirsh D, Heinrichs C, Leenders B, Wong AC, Cummings DE, Chanoine JP.  Ghrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone release.  Horm Res 63:111-118 (2005).

Cummings DE, Overduin J, Foster-Schubert KE.  Roles for ghrelin in the regulation of appetite and body weight.  Curr Opin Endo Diabetes 12:72-79 (2005).

Foster-Schubert KE, McTiernan A, Frayo RS, Rajan KB, Yasui Y, Tworoger SS, Cummings DE.  Human plasma ghrelin levels increase during a one-year exercise program. 
J Clin Endocrinol Metab 90:820-825 (2005).

Cummings DE, Foster-Schubert KE, Overduin J.  Ghrelin and energy balance: focus on current controversies.  Curr Drug Targets 6:153-169 (2005).

Overduin J, Frayo RS, Grill HJ, Kaplan JM, Cummings DE.  Role of the duodenum and macronutrient type in ghrelin regulation.  Endocrinology 146:845-850 (2005).

Cummings DE, Carlson MJ, Shannon MH.  The obesity pandemic and research horizons.  Endo News 30:20-22 (2005).

Stefan M, Ji H, Simmons RA, Cummings DE, Ahima RS, Friedman MI, Nicholls RD.  Hormonal and metabolic defects in a Prader-Willi syndrome mouse model with neonatal failure to thrive.  Endocrinology 146:4377-4385 (2005).

Cummings DE, Overduin J, Shannon MH, Foster-Schubert KE.  Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery.  Surg Obes Relat Dis 1:358-388 (2005).

Consensus Conference Panel.  Consensus conference statement on bariatric surgery for morbid obesity: health implications for patients, health professionals, and third-party payers.  Surg Obes Rel Dis 1:371-381 (2005).

Cummings DE.  Gastric bypass and nesidioblastosis – too much of a good thing for islets?  New Engl J Med 353:300-302 (2005).

Allison KC, Ahima RS, O’Reardon JP, Dinges DF, Sharma V, Cummings DE, Heo M, Martino NS, Stunkard AJ.  Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome.  J Clin Endocrinol Metab 90:6214-6217 (2005).

Naleid AM, Grace MK, Cummings DE, Levine AS.  Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens.  Peptides 26:2274-2279 (2005).

Cummings DE, Shannon MH, Carlson MJ.  Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery.  New Engl J Med 353:2192-2194 (2005).

Griffen S, Oostema K, Stanhope K, Graham J, Styne D, Glaser N, Cummings DE, Connors MH, Havel PJ.  Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin compared with regular/NPH insulin in female patients with type-1 diabetes.  J Clin Endocrinol Metab 91:485-491 (2006).

Cummings DE.  Ghrelin and the short- and long-term regulation of appetite and body weight.  Physiol Behav 89:71-84 (2006).

Yukawa M, Cummings DE, Matthys CC, Callahan HS, Frayo RS, Spiekerman CF, Weigle DS.  Effect of aging on the response of ghrelin to acute weight loss. J Am Geriatr Soc 54:648-653 (2006).

Shannon MH, Cummings DE.  Hunger and memory: Can ghrelin help us remember where to find dinner?  Cell Science 3:1 (2006).

Rubino F, Forgione A, Cummings DE, Vix M, Gnuli D, Mingrone G, Castagneto M, Marescaux J.  The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes.  Ann Surg 244:741-749 (2006).

Carlson MJ, Cummings DE.  Prospects for an anti-ghrelin vaccine to treat obesity.  Molec Interv 6:249-252 (2006).

Mundinger TO, Cummings DE, Taborsky GJ Jr.  Direct stimulation of ghrelin secretion by sympathetic nerves.  Endocrinology 147:2893-2901 (2006).

Littman AJ, Vitiello MV, Foster-Schubert K, Ulrich CM, Tworoger SS, Potter JD, Weigle DS, Cummings DE, McTiernan A.  Sleep, ghrelin, leptin, and changes in body weight during a 1-year moderate-intensity physical activity intervention.  Int J Obes (Epub ahead of print).

Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW.  Central nervous system control of food intake and body weight.  Nature 443:289-295 (2006).

Foster-Schubert KE, Cummings DE.  Emerging therapeutic strategies for obesity.  Endocr Reviews 27:779-793 (2006).

Patel JV, Cummings DE, Girod JP, Mascarenhas AV, Hughes EA, Gupta M, Lip GY, Reddy S, Brotman DJ.  Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment. J Neg Res Biomed 5:14-21 (2006).

Williams DL, Grill HJ, Cummings DE, Kaplan JM.  Overfeeding-induced weight gain suppresses plasma ghrelin levels in rats.  J Endocrinol Invest 29:863-868 (2006).

Erdie-Lalena CR, Holm VA, Kelly PC, Frayo RS, Cummings DE.  Ghrelin levels in young children with Prader-Willi syndrome.  J Pediatr 149:199-204 (2006).

Purnell JQ, Cummings DE, Weigle DS.  Changes in 24-hour area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity.  Int J Obes 31:385-389 (2007).

Cummings DE, Overduin J, Foster-Schubert KE, Carlson MJ.  Role of the bypassed proximal intestine in the anti-diabetic effects of bariatric surgery. Surg Obes Relat Dis 3:109-115 (2007).

Cummings DE, Naleid AM, Figlewicz Lattemann DP.  Ghrelin: a link between energy homeostasis and drug abuse?  Addict Biol 12:1-5 (2007).

Cummings DE, Overduin J.  Gastrointestinal regulation of food intake. 
J Clin Invest 117:13-23 (2007).

Devlin A, Wright AS, Figueredo E, Alyea E, Hanley PW, Lucas MK, Cummings DE.  Development of a porcine Roux-en-Y gastric bypass survival model for the study of post-surgical physiology.  Obes Surg 17:1332-1339 (2007). 

Lasseter KC, Shaughnessy L, Cummings D, Pezzullo JC, Wargin W, Gagnon R, Oliva J, Kosutic G.  Ghrelin agonist (TZP-101): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-man study.  J Clin Pharmacol 48:193-202 (2008). 

Taleban S, Carew HT, Dichek HL, Deeb SS, Hollenback D, Weigle DS, Cummings DE, Brunzell JD.  Energy balance in congenital generalized lipodystrophy type I.  Metabolism 57:1155-1161 (2008).

LABS Writing Group for the LABS Consortium.  Relationship of body mass index with demographic and clinical characteristics in the Longitudinal Assessment of Bariatric Surgery (LABS).  Surg Obes Relat Dis 4:474-480 (2008). 

Schur EA, Cummings DE, Callahan HS, Foster-Schubert KE.  Association of cognitive restraint with ghrelin, leptin, and insulin levels in subjects who are not weight-reduced.  Physiol Behav 93:706-712 (2008).

Goel N, Stunkard AJ, Rogers NL, van Dongen H, Allison KC, O’Reardon JP, Ahima RS, Cummings DE, Heo M, Dinges DF.  Circadian rhythm profiles in women with night eating syndrome.  J Biol Rhythms (in press).  

Karaoglu A., Cummings DE, Aydin S.  Expression of obestatin and ghrelin in papillary thyroid carcinoma.  Molec Cell Biochem (in press). 

Cummings DE, Flum DR.  Gastrointestinal surgery as a treatment for diabetes.  JAMA 299:341-343 (2008). 

Heap AJ, Cummings DE.  A novel weight-reducing operation: lateral subtotal gastrectomy with silastic ring plus small bowel reduction with omentectomy.  Obes Surg 8:819-828 (2008).

Thaler JP, Cummings DE.  Metabolism: food alert.  Nature 452:941-942 (2008). 

Foster-Schubert KE, Overduin J, Prudom CE, Liu J, Callahan HS, Gaylinn BD, Thorner MO, Cummings DE.  Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates.  J Clin Endocrinol Metab 93:1971-1979 (2008).