Chang Yeop Han, PhD
Title:
Research Assistant Professor, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition
Email Address:
Background:
Dr. Han received his MS from Sung Kyun Kwan University and his PhD from Korea University, Seoul, Republic of Korea. In 2003, he joined the laboratory of Dr. Alan Chait as Post-doctoral fellow at the University of Washington, Seattle. After completing postdoctoral training, he is currently a Research Assistant Professor at the Diabetes and Obesity Center of Excellence in the Department of Medicine at the University of Washington, Seattle.
Focus:
Dr. Han's research focuses on the adipose tissue inflammation in obesity. Obesity is characterized by adipocyte hypertrophy and accumulation of macrophages in adipose tissue. Both adipocytes and macrophages secrete a number of pro-inflammatory molecules, which may lead to insulin resistance, systemic inflammation and cardiovascular disease. He is especially interested in how adipocytes produce chemotactic factors to recruit monocytes and extracellular matrix molecules to increase the adhesion of macrophages by nutrient excess such as excess glucose and various free fatty acids. He is studying potential mechanisms involved in reactive oxygen species, interaction between NFKB and PPAR, Toll-like receptor and NADPH oxidase at hypertrophic adipocyte. He is also studying how adipocytes cross-talk with macrophage to determine the phenotype of macrophage in obesity.
Representative Publications:
Han CY, Campbell JS, Fausto N, Chaisson M, Orasanu G, Plutzky J and Chait A: Reciprocal regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocyte. Arterioscler Thromb Vasc Biol 26:1806-1813, 2006.
Han CY, Subramanian S, Chan CK, Omer M, Chiba T, Wight TN and Chait A: Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 56: 2260-2273, 2007.
Subramanian S, Han CY, Chiba T, McMillen T, Wang SA, Kirk EA, O’Brien KD, and Chait A: Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese, insulin resistant LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 28:685-691, 2008.
Chiba T, Han CY, Shimokado K, Chen M, Wang S, Vaisar T, Heinecke JW, and Chait A: Serum amyloid A3 (SAA3), an adipocyte-derived inflammatory protein, does not contribute directly to the increased circulating SAA levels seen in obese mice. J Lipid Res 50:1353-1362, 2009
Han CY, Kargi AY, Omer M, Chan CK, O’Brien KO, Wight TN and Chait A: Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. Diabetes 59:386-396, 2010
Current Collaborations:
Within the Diabetes and Obesity Center of Excellence and its Affiliated Members
Alan Chait, MD
Chongren Tang, PhD
Tomas Vaisar, PhD
William Osborne, PhD
Francis Kim, MD
Outside the Diabetes and Obesity Center of Excellence
Kevin O’Brien, MD, University of Washington
Thomas Wight, PhD, Benaroya Research Institute