The Diabetes and Obesity Center of Excellence at the University of Washington

We work together for a future free of disease related to diabetes and obesity

Learn About Our Programs

The Center draws upon the expertise of a wide range of investigators with complementary interests in diabetes, obesity, inflammation, lipid metabolism and atherosclerosis. Members of the Center’s faculty conduct both basic research to clarify the mechanisms causing diabetes and obesity and their consequences, and translational research to transform their research findings into clinical solutions.

Disease Information

Two-thirds of the adult U.S. population is overweight and one-half of those individuals – one-third of the adult population – are obese. The prevalence of type 2 diabetes (formerly known as “adult-onset”) has also increased markedly in recent decades not only among adults, but in children as well. Although type 1 diabetes is less common, it is a potentially devastating disorder affecting both children and adults and, while treatments for both types of diabetes exist, neither is curable and effective treatments for obesity have yet to be developed.

How To Get Involved

Much of the good we accomplish is made possible by private support: by people and organizations underwriting leading-edge research and providing funding to train promising fellows. With your help, the DOCE is improving lives throughout the Northwest and around the world.

Our Research Programs

Latest News and Events

DOCE Director Michael Schwartz, MD and Novo Nordisk collaborate on exploring the role of the brain in regulating blood glucose and obesity

Dr. Michael Schwartz is collaborating with Novo Nordisk on a three-year project to explore the role of the brain in regulating blood glucose and obesity. The collaboration aims to understand factors mediating brain control of blood glucose and appetite with the ultimate goal of developing new therapeutic agents for the treatment of diabetes and obesity.…

DOCE Director Michael Schwartz, MD, Featured in Sigma Podcast

SNR #89: Dr. Michael Schwartz – Role of the Brain in Obesity, Insulin Resistance and Type 2 Diabetes Pathogenesis.

DOCE Associate Director Karin Bornfeldt, PhD, Receives NIH R01 Award

The project, entitled Obesity and Arterial Metabolism, focuses on the overall hypothesis is that expression of the glucose transporter GLUT1 is of critical importance for the obesity-induced arterial metabolic signature, smooth muscle cell phenotype, and obesity-accelerated atherosclerosis.

NHLBI Renews Cardiovascular Disease and Diabetes Program Project (PI: Karin Bornfeldt, DOCE Associate Director)

The focus of the program project is to investigate whether diabetes causes high-density lipoprotein to lose its cardioprotective effects and whether this contributes to the increased cardiovascular disease risk associated with diabetes.

DOCE Researcher Ian Sweet, PhD, and Colleague Receive ADA Innovation Award

Drs. Wang Wang and Ian Sweet have been awarded an American Diabetes Association Innovative Award for their project entitled ‘Source and sites of action of hydrogen peroxide in mitochondria and cytosol of pancreatic islets’.

DOCE Researcher Ian Sweet, PhD, Receives NIH STTR Award

Dr. Ian Sweet has been awarded an NIH Small Business Technology Transfer (STTR) award for his project entitled ‘Continuous measurement of cell growth as an optimal tool in drug toxicity testing’.

DOCE Director Michael Schwartz, MD, Featured in UW Medicine Magazine

The article, entitled “Diabetes & Obesity via the Brain” focuses on the Schwartz Laboratory’s use of optogentics to understand the neurocircuitry activated in diabetes with the goal to develop new opportunities to treat or prevent the disease

DOCE Researcher Christiane Hampe, PhD, Receives T1D Exchange Biobank Pilot Award

Dr. Christiane Hampe has received a one year pilot research award through the T1D Exchange Biobank Operations Center at the Benaroya Research Institute (BRI)

DOCE Researcher Christiane Hampe, PhD, Receives National Ataxia Foundation Award

Dr. Christiane Hampe has received an award from the National Ataxia Foundation for her project entitled Glutamate Decarboxylase in Cerebellar Ataxia.

DOCE Director Michael Schwartz, MD, Cross-published in Endocrine Society Journals

Dr. Michael Schwartz is author of a recent editorial entitled Can the History of Modern Endocrinology Shape the Future of Obesity?