Brent Wisse, MD
Title:
Associate Professor, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition
Email Address:
Background:
Dr. Wisse received his MD and Internal Medicine training at McGill University in 1995 before completing his fellowship training in Endocrinology and Metabolism at the UW. During his fellowship, Dr. Wisse worked with with Dr. David Cummings and Dr. Michael Schwartz. Dr. Wisse joined the UW Faculty in 2001 and he enjoys clinical teaching and patient care responsibilities at Harborview Medical Center (HMC) in Seattle, and also has served as Director of the HMC Glycemic Control Service since 2007. His research program focuses on the intersection between inflammatory signals and energy homeostasis and is a member of the Western Federation of Medical Research, the Endocrine Society, and The Obesity Society. His research efforts have been NIH funded since 2001.
Focus:
Dr. Wisse's research focuses on the following areas:
Central pathways regulating anorexia and cachexia
This area has been a principal research focus, identifying key CNS signals whereby systemic inflammatory mediators cause anorexia and weight loss, including cachexia – the specific wasting of skeletal muscle.
Diabetes and Obesity Center of Excellence Collaborators include: Michael Schwartz, MD; Greg Morton, PhD; Renee Leboeuf, PhD; and Jay Heinecke, MD.
Nutrient excess as an inflammatory stimulus
This program focuses on the response of hypothalamic cell lines and primary neuronal cultures to excess nutrients from glucose or fatty acids.
Diabetes and Obesity Center of Excellence Collaborators include: Francis Kim, MD; Michael Schwartz, MD; Greg Morton, PhD; Ian Sweet, PhD; and Jay Heinecke, MD.
Regulation of Spontaneous Physical Activity (SPA) in mice
A new area of interest, this program is designed to identify the physiological regulators of voluntary activity and the influence on non-resting energy expenditure and body weight regulation in mice.
Diabetes and Obesity Center of Excellence Collaborators include: Michael Schwartz, MD; Greg Morton, PhD, Karl Kaiyala, PhD, Renee LeBoeuf, PhD.
Representative Publications:
Wisse BE, Ogimoto K, Schwartz MW. Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins. Peptides. 27:265-273, 2006.
Ogimoto K, Harris MK Jr, Wisse BE. MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology. 147:4445-4553, 2006.
Wisse BE, Ogimoto K, Morton GJ, Williams DL, Schwartz MW. Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance. Brain Res. 1144:101-106, 2007.
Wisse BE, Ogimoto K, Tang J, Harris MK Jr, Raines EW, Schwartz MW. Evidence that LPS-induced anorexia depends upon central, rather than peripheral, inflammatory signals. Endocrinology. 148:5230-5237, 2007.
Wisse BE, Kim F, Schwartz MW. Physiology. An integrative view of obesity. Science. 318:928-929, 2007.
Wisse BE, Schwartz MW. Does hypothalamic inflammation cause obesity? Cell Metabolism. 10:241-242, 2009.
Choi SJ, Kim F, Schwartz MW and Wisse BE. Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am J Physiology. 298:E1122-1130, 2010. PMCID: PMC2886534.
View Expanded Publication List
Current Collaborations:
Within the Diabetes and Obesity Center of Excellence and its Affiliated Members
Michael Schwartz, MD
Greg Morton, PhD
Renee Lebeouf, PhD
Jay Heinecke, MD
Francis Kim, MD
Ian Sweet, PhD
Tomas Vaisar, PhD
Lab Members:
Xiaolin Zhao, MD
JD Fischer, BS
Tracy Tylee, MD