Ian Sweet PhD - Expanded Publication List

Sweet IR, Gustafson SS, Ramkrishna D. Population balance modeling of bubbling fluidized bed reactors-I. Well-stirred dense phase. Chemical Eng. Sci. 42:341-351, 1987.

Vong RJ, Larson TV, Zoller WH, Covert DS, Charlson RJ, Sweet I, Peterson R, Miller T, Oloughlin JF, Stevenson MN.  Rainwater chemistry near an isolated SO2 emission source.  ACS Symposium Series.  349: 204-212, 1987.

Weigle DS, Sweet IR, Goodner CJ.  A kinetic analysis of hepatocyte responses to a glucagon pulse: Mechanism and metabolic consequences of differences in response decay times. Endocrinology 121:732-737, 1987.

Goodner CJ, Sweet IR, Harrison HC Jr. Rapid reduction and return of surface insulin receptors after exposure to brief pulses of insulin in perifused rat hepatocytes.  Diabetes  37:1316-1323, 1988.

Koerker DJ, Sweet IR, Baskin DG. Insulin binding to individual rat skeletal muscles. Am. J. Physiol. 259:E517-E523, 1990.

Kroll K, Deussen A, Sweet IR. A model of the transport and metabolism of adenosine and S-adenosylhomocysteine (SAH) in the heart.  Circ. Res. 71:590-604, 1992.

Sweet IR, Matschinsky FM.  Mathematical model of ß-cell glucose metabolism and insulin release. I. Glucokinase as glucosensor hypothesis. Am. J. Physiol. 268:E775-E788, 1995.

Sweet IR, Peterson L, Kroll K, Goodner CJ, Berry MA, Graham M. Effect of glucose on uptake of radiolabeled glucose, 2-DG and 3-O-MG by the perfused rat liver. Am J Physiol. 271:E384-96, 1996.

Sweet IR, Najafi H, Li G, Berner DK, Matschinsky FM. Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets. Am. J. Physiol. 271:E606-E625, 1996.

Matschinsky FM, Sweet IR.  Annotated questions and answers about glucose metabolism and insulin secretion of beta-cells. Diabetes Reviews. 4:130-144, 1996.

Sweet IR, Najafi H, Li G, Grodberg J, Matschinsky FM.  Measurement and modeling of glucose-6-phosphatase in pancreatic islets.  Am. J. Physiol. 272:E696-E711, 1997.

Sweet IR, Matschinsky FM. Are there kinetic advantages to GLUT2 in pancreatic glucose sensing? Diabetologia 40:112-119, 1997.

P. Kesavan, Wang L, Davis E, Cuesta A, Sweet IR, Niswender K, Magnuson MA, Matschinsky FM.  Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity onset diabetes of the young (type-2). Biochem. J.  322:57-63, 1997.

Doliba NM, Sweet IR, Babsky A, Doliba N, Forster RE, Osbakken M.  Simultaneous measurement of oxygen consumption and 13C16O2 production from 13C-pyruvate in diabetic rat heart mitochondria. Adv. Exp. Med Biol. 428:269-275, 1997.

Davis EA, Cuesta-Munoz A, Raoul M, Buettger C, Sweet IR, Moates M, Magnuson MA, Matschinsky FM.  Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Diabetologia 42:1175-86, 1999.

Sweet IR, DL Cook, RW Wiseman, CJ Greenbaum, Å Lernmark, S Matsumoto, JC Teague, KA Krohn.  Dynamic perifusion to maintain and assess isolated pancreatic islets.  Diabetes Tech. Ther.  4:67-76, 2002.

Chessler SD,Simonson W, Sweet IR, Hammerle LP. Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets. Diabetes 51:1763-71,2002.

Matsumoto S, Qualley SA, Goel S, Hagman DK, Sweet IR, Poitout V, Strong DM, Robertson RP, Reems JA.  Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol.  Transplantation 74:1414-9, 2002.

Sweet IR, G Khalil, AR Wallen, M Steedman, KA Schenkman, JA Reems, SE Kahn, JB Callis. Continuous measurement of oxygen consumption by pancreatic islets. Diabetes Tech. Ther.  4: 661-672, 2002.

Sweet IR, DL Cook, E DeJulio, AR Wallen, G Khalil,, JB Callis, JA Reems. Regulation of ATP/ADP in pancreatic islets. Diabetes  53:401-409, 2004.

Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Wallen AR, Marcum ES, Stekhova SA, Krohn KA.  Systematic screening of potential beta-cell imaging agents.  Biochem Biophys Res Commun. 314: 976-83, 2004.

Sweet IR, Cook DL, Lernmark Å, Greeenbaum CJ, Krohn KA.  Non-invasive imaging of beta cell mass: a quantitative analysis.  Diabetes Tech Ther, 6: 652-659, 2004.

Hampe CS, Wallen AR, Binder K, Schlosser M, Ziegler M, Sweet IR.  Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass.  Exp Clinical Endo Diabetes, 113: 381-7, 2005.

Niswender CM, Willis BS, Wallen A, Sweet IR, Jetton TL, Thompson BR, Wu C, Lange AJ, McNight GS.  Dre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.  Genesis.  43: 109-119, 2005.

Sweet IR, Gilbert, Sabek O, Fraga DW, Gaber AO, Reems JA. Glucose stimulation of cytochrome c reduction and oxygen consumption as assessment of human islet quality. Transplantation  80: 1003-1011, 2005.

Nunemaker CS, Wasserman DH, McGuinness OP, Sweet IR, Teague JC, Satin LS.  Insulin secretion in the conscious mouse is biphasic and pulsatile.  Am J Physiol Endocrinol Metab. 290: E523-9 2006.

Suckow AT, Sweet IR, Yserloo BV, Rutledge EA, Hall T, Waldrop M, Chessler SD.   Identification and characterization of a novel isoform of the vesicular GABA transporter with glucose-regulated expression in rat islets.  J Mol Endo, 36: 187-99, 2006.

Sweet IR, Gilbert M. Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic islets.  Diabetes 55: 3509-19, 2006.

Weydt, P, Pineda VV, Torrence AE, Libby RT, Satterfield TF, Lazarowski ER, Gilbert M, Morton GJ, Bammler TK, Stramd AD, Cui L, Beyer RP, Easley CN, Smith AC, Krainc D, Luquet S, Sweet IR, Schwartz MW, La Spada AR.  Thermoregulatory and metabolic defects in Huntington’s disease transgenic mice implicate PGC-1a in Huntington’s disease neurodegeneration  Cell Metabolism, 4: 349-62, 2006.

Schwartz PS, Manion MK, Emerson CB, Fry JS, Schulz CM, Sweet IR, Hockenbery DM.  2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition. Molecular Cancer Therapeutics, 6: 2073-80, 2007.

Sweet IR, Gilbert M, Scott S, Todorov I, Jensen R, Nair I, Al-Abdullah I, Rawson J, Mullen Y, Kandeel F, Ferreri K.  Glucose-stimulated increment in oxygen consumption rate as a standardized test of human islet quality.  Amer. J. Trans. 8:183-192, 2008.

Sweet IR, Yanay O, Waldron L, Gilbert M, Fuller J, Tupling T, Lernmark A, Osborne B.  Treatment of Diabetic Rats with Encapsulated Islets.  J. Cell Mol. Biol. 12:2644-50, 2008.

Raffo A, Hancock K, Polito T, Witkowski P, Ferrara C, Freeby M, Maffei A, Leibel R, Goland R, Sweet IR, Harris PE.  Role of vesicular monoamine transporter type 2 in insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.  J of Endocrinology, 198:41-9, 2008.

Gilbert M, Jung S-R, Sweet IR. Increased potency of calcium derived from L-type calcium channels compared to calcium from the endoplasmic reticulum on oxygen consumption and insulin secretion. J. Biol. Chem. 283:24334-42, 2008.

Cummings BP, Digitale EK, Stanhope KL, Graham JL, Baskin DG, Reed BJ, Sweet IR, Griffen SC, Havel PJ.  Development and Characterization of a Novel Rat Model of Type 2 Diabetes Mellitus: The UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rat.  Am. J. Physiol. 295:R1782-93, 2008.

Jung S-R, Reed BJ, Sweet IR.  A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta cells. Am J Physiol. (Epub) 2009.

Sweet IR, Gilbert M, Maloney E, Hockenbery DM, Schwartz MW, Kim F. Endothelial inflammation induced by excess glucose is linked to intracellular accumulation of glucose-6-phosphate. Diabetalogia 52:921-3, 2009.

Bollyky PL, Bice JB, Sweet IR, Falk BA, Gebe JA, Clark AE, Gersuk VH, Aderem A, Hawn TR, Nepom GT.  The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS ONE 4:e5063. 2009.

Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S, Handa P, Schwartz MW, Kim F.  Activation of NF-{kappa}B by palmitate in endothelial cells. A key role for NADPH Oxidase-derived superoxide in response to TLR4 Activation.  Arterioscler Thromb Vasc Biol (Epub) 2009.

Jung S-R, Reed BJ, Sweet IR. A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta cells. Am J Physiol. (Epub) 2009.