Karin Bornfeldt PhD - Expanded Publication List

Bornfeldt KE, Gidlöf RA, Wasteson Å, Lake M, Skottner A & Arnqvist HJ (1991): Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities. Diabetologia. 34, 307-313.

Bornfeldt KE, Raines EW, Nakano T, Graves LM, Krebs EG & Ross R (1994): Insulin-like growth factor-I and platelet-derived growth factor-BB inducedirected migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J Clin Invest.  93,1266-1274.

Bornfeldt KE, Graves LM, Raines EW, Igarashi Y, Wayman G, Yamamura S, Yatomi Y, Sidhu JS, Krebs EG, Hakomori S & Ross R (1995): Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemotactic signal transduction. J. Cell Biol.  130, 193-206.

Graves LM, Bornfeldt KE, Argast GM, Krebs EG, Kong X, Lin TA & Lawrence JC Jr (1995): cAMP- and rapamycin-sensitive regulation of the association ofeukaryotic initiation factor 4E and the translational regulator PHAS-1 in aortic smooth muscle cells. Proc Natl Acad Sci USA.  92, 7222-7226.

Graves LM, Bornfeldt KE, Sidhu JS, Argast GM, Raines EW, Ross R, Leslie CC & Krebs EG (1996): Platelet-derived growth factor stimulates protein kinase Athrough a mitogen-activated protein kinase dependent pathway in human arterial smooth muscle cells. J Biol Chem. 271, 505-511.

Koyama H, Raines EW, Bornfeldt KE, Roberts JM & Ross R (1996): Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation ofcdk2 inhibitors. Cell.  87, 1069-1078.

Bornfeldt KE, Campbell JS, Koyama H, Argast GM, Leslie CC, Raines EW, Krebs EG & Ross R (1997): The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells: Dependence on the availability of downstream targets. J Clin Invest. 100, 875-885.

Rybalkin SD, Bornfeldt KE, Sonnenburg WK, Rybalkina IG, Kwak KS, Hanson K, Krebs EG & Beavo JA (1997):  Calmodulin-stimulated cyclic nucleotidephosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. J Clin Invest. 100, 2611-2621.

Zhao AZ, Bornfeldt KE & Beavo JA (1998): Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest.  102, 869-873.

Zhao AZ, Shinohara MM, Huang D, Eldar-Finkelman H, Krebs EG, Beavo JA & Bornfeldt KE (2000): Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes.  J Biol Chem. 275, 11348-11354.

Suzuki LA, Poot M, Gerrity RG & Bornfeldt KE (2001): Diabetes accelerates smooth muscle accumulation in atherosclerotic lesions: Lack of direct growthpromoting effects of high glucose levels. Diabetes. 50, 851-860.

Renard CB & Bornfeldt KE (2001): Human arterial smooth muscle cells rapidly deplete cell culture media of glucose. Diabetologia. 44, 1067-1068.

Wong ST, Baker LP, Trinh K, Hetman M, Suzuki LA, Storm DR & Bornfeldt KE (2001): Adenylyl cyclase 3 mediates prostaglandin E2-induced growth inhibitionin arterial smooth muscle cells.  J Biol Chem. 276, 34206-34212.

Rybalkin SD, Rybalkina IG, Beavo JA & Bornfeldt KE (2002): Calmodulin-dependent cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation. Circ Res. 90, 151-157.

Askari B, Renard CB & Bornfeldt KE (2002): Regulation of smooth muscle accumulation in diabetes-accelerated atherosclerosis.  Histol Histopathol. 17,1317-1328.

Askari B, Carroll MA, Capparelli M, Kramer F, Gerrity RG & Bornfeldt KE (2002): Oleate and linoleate enhance the growth-promoting effects of IGF-Ithrough a phospholipase D-dependent pathway in arterial smooth muscle cells. J Biol Chem.  277, 36338-36344.

Bornfeldt KE (2003): The cyclin-depentent kinase pathway moves forward. Circ Res. 92, 345-347.

Yokota T, Ma R, Park J-Y, Isshiki K, Sotiropoulos K, Raunniyar R, Bornfeldt KE & King GL (2003): Role of protein kinase C on the expression ofplatelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes.  52, 838-845.

Renard CB, Askari B, Suzuki LA, Kramer F & Bornfeldt KE (2003): Oleate, not ligands for the receptor of advanced glycation end-products, promotesproliferation of human arterial smooth muscle cells. Diabetologia. 46, 1676-1687.

Rybalkin SD, Chen Y, Bornfeldt KE & Beavo JA (2003): Cyclic GMP-phosphodiesterases and regulation of arterial smooth muscle function. Circ Res. 93,280-291.

Oram JF & Bornfeldt KE (2004): Direct effects of long-chain non-esterified fatty acids on vascular cells and relevance to macrovascular complications ofdiabetes. Front Biosci. 9, 1240-1353.

Lamharzi N, Renard CB, Kramer F, Pennathur S, Heinecke JW, Chait A & Bornfeldt KE (2004): Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: Potential role of glucose-oxidized LDL. Diabetes. 53, 3217-3225.

Renard CB, Kramer F, Johansson F, Lamharzi N, Tannock LR, von Herrath MG, Chait A, Bornfeldt KE (2004): Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest. 114, 659-668.

Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ,Nebert DW, Renieri A, Schaffer JE, Stahl A, Watkins PA, Vasiliou V, Yamamoto TT (2004): Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res. 45, 1958-1961.

Dekker Nitert M, Chisalita SI, Olsson K, Bornfeldt KE & Arnqvist HJ (2005): IGF-I/insulin hybrid receptors in human endothelial cells. Mol Cell Endocrinol. 229, 31-37.

Bornfeldt KE (2006): Nuclear signaling in smooth muscle cells: cyclic nucleotide phosphodiesterase 1A moves in. Circ Res. 98, 720-722.

MacDougall ED, Kramer F, Polinsky P, Barnhart S, Askari B, Johansson F, Rosenfeld ME, Oka K, Chan L, Schwartz SM & Bornfeldt KE (2006): Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low fat diet regimen induces regression and reducesmacrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice.  Am J Pathol. 168, 2064-2073.

Bornfeldt KE (2006): A single second messenger. Several possible cellular responses depending on distinct subcellular pools.  Circ Res. 99, 790-792.

Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA & Bornfeldt KE (2007): Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a PPAR-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes. 56, 1143-1152.

Kanter JE, Johansson F, LeBoeuf RC & Bornfeldt KE (2007): Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques?  Circ Res. 100, 769-781.

Shen X & Bornfeldt KE (2007): Mouse models for cardiovascular complications of type 1 diabetes.  Ann New York Acad Sci. 1103, 202-217.

Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW & Bornfeldt KE (2008): Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci USA. 105, 2082-2087.

Zeng H, Horie K, Madisen L, Pavlova MN, Gragerova G, Rohde AD, Schimpf BA, Liang Y, Ojala E, Kramer F, Roth P, Slobodskaya O, Dolka I, Southon EA, Tessarollo L, Bornfeldt KE, Gragerov A, Pavlakis GN, Gaitanaris GA (2008): An inducible and reversible mouse genetic rescue system. PLoS Genet., e1000069, 1-13.

Kanter JE, Averill MM, LeBoeuf RC & Bornfeldt, KE (2008): Diabetes-accelerated atherosclerosis and inflammation. Circ Res. 103, e116-e117.

Chait A, Bornfeldt KE (2009): Diabetes and atherosclerosis: Is there a role for hyperglycemia? J Lipid Res. 50 Suppl, S335-339.

Averill MM, Bornfeldt KE (2009): Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes. Curr Diabetes Rep. 9, 18-25.

Li S, Sun Y, Liang CP, Thorp EB, Han S, Jehle AW, Saraswathi V, Pridgen B, Kanter JE, Li R, Welch CL, Hasty AH, Bornfeldt KE, Breslow JL, Tabas I, Tall AR (2009): Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res. 105, 1072-1082.

Tang C, Kanter JE, Bornfeldt KE, Leboeuf RC, Oram JF (2010): Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys. J Lipid Res. 51, 1719-1728.

Cardoso LE, Little PJ, Ballinger ML, Chan CK, Braun KR, Potter-Perigo S, Bornfeldt KE, Kinsella MG, Wight TN (2010): Platelet-derived growth factor differentially regulates the expression and post-translational modification of versican by arterial smooth muscle cells through distinct protein kinase C and extracellular signal-regulated kinase pathways. J Biol Chem. 285, 6987-6995.

Raines EW, Bornfeldt KE (2010): Integrin alpha(7)beta(1) COMPels smooth muscle cells to maintain their quiescence. Circ Res. 106, 427-429.