William R.A. Osborne PhD - Expanded Publication List

Adam MA, Ramesh N, Miller AD, Osborne WRA: Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions. J Virol 65:4985-4900, 1991.

Ramesh N, Shin YL, Lau S, Osborne WRA: High-level expression from CMV promoter in macrophage cells.  Hum. Gene Ther. 6:1323-1327, 1995.

Osborne WRA, Ramesh N, Lau S, Clowes MM, Dale DC, Clowes AD: Gene therapy for long-term expression of erythropoietin in rats. Proc. Natl. Acad. Sci. USA 92:8055-8058, 1995.

Wei MQ, Lejnieks DV, Ramesh N, Lau S, Seppen J, Osborne WRA: Sustained gene expression in transplanted skin fibroblasts in rats.  Gene Therapy 6:840-844, 1999.

Seppen J, Barry S, Lam GM, Ramesh N, Osborne WRA: Retroviral preparations derived from PA317 packaging cells contain inhibitors that co-purify with viral particles and are devoid of viral vector RNA. Human Gene Therapy 11:771-775, 2000.

Barry SC, Seppen J, Ramesh N, Foster, JL, Ochs HD, Garcia JV, Osborne WRA: Lentiviral and Murine retroviral transduction of T-cells for expression of human CD40 ligand. Human Gene Therapy 11:323-332, 2000.

Barry SC, Ramesh N, Lejnieks DV, Simonson WT, Kemper L, Lernmark A, Osborne WRA: Glucose-regulated insulin expression in diabetic rats. Human Gene Therapy, 12:131-139, 2001.

Seppen J, Barry SC, Harder B, Osborne WRA: Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin.  Blood, 98:594-596, 2001.

Barry SC, Harder B, Brzezinski M, Flint LY, Osborne WRA:  Lentivirus vectors encoding both central polypurine tract and posttranscriptional regulatory element provide enhanced transduction and transgene expression.  Human Gene Therapy,  12:1103-1108, 2001.

Freitas AC, Bento FM, Ramesh N, Osborne WRA, Han SW: Modified basticidin S resistance gene (bsrm) as a selectable marker for construction of retroviral vectors.  J Biotechnology, 95:57-62, 2002.

Katen LJ, Aprikyan AG, Dale DC, Osborne WRA: Cloning and sequencing of the canine neutrophil elastase cDNA. DNA Sequence, 13:221-223, 2002.

Yanay O, Barry SC, Katen LJ, Brzezinski M, Flint LY, Christensen J, Liggitt D, Dale DC, Osborne WRA: Treatment of canine cyclic neutropenia by lentivirus-mediated G-CSF delivery. Blood 102:2046-2052, 2003.

Yanay O, Flint LY, Brzezinski M, Barry SC, Barton RW, Osborne WRA: Long term erythropoietin gene expression form transduced cells in bioisolator devices.  Human Gene Therapy 14: 1587-1593, 2003.

Barry S, Brzezinski M,Yanay O, Seppen JE, Osborne WRA: Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery. J Gene Med 7: 1510-1516, 2005.

Yanay O, Brzezinski M, Christensen J, Liggitt D. Dale DC. Osborne, WRA: An adult dog with cyclic neutropenia treated by lentivirus-mediated G-CSF delivery. Human Gene Therapy 17: 464-469, 2006.

Fitzgerald SM, Goyal RK, Osborne WRA, Roy JD, Wilson JW, Ferrell RE: Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter. Human Genetics 119:276-283, 2006.

Brzezinski M, Yanay O, Waldron L, Barry SC, Osborne WRA. G-CSF-lentivirus administration in rats provided sustained elevated neutrophil counts and subsequent EPO-lentivirus administration increased hematocrits. J Gene Med 9:571-578, 2007.

Yanay, O. IR Sweet, L Waldron, M Brzezinski, ML Gilbert, JM Fuller, T Tupling, A Lernmark, Osborne, W.R.A. L Waldron, M Brzezinski, JM Fuller, T Tupling, EA Rutledge, A Lernmark. Lentivirus-mediated Gimap5 gene delivery to treat diabetic BB rats. Molecular Therapy, 15,Supplement 1, S41 2007.

Tatake R, M. ON, Kennedy C, Hikel V, Runyan V, Monaco K-A, Yu K, Osborne W, Barton R, Schneiderman R: Glucose-regulated insulin production from genetically engineered human non-beta cells. Life Sciences, 81:1346-1354, 2007.

Sweet IR, Yanay O, Waldron L, Gilbert M, Fuller JM, Tupling T, Lernmark A, Osborne WRA: Treatment of Diabetic Rats with Encapsulated Islets. Journal of Cellular and Molecular Medicine, Epub ahead of print, 2008.